Leonard Petrucelli Selected Research

poly(glycyl-alanyl)

1/2022	Poly(GR) and poly(GA) in cerebrospinal fluid as potential biomarkers for C9ORF72-ALS/FTD.
4/2021	C9orf72 poly GA RAN-translated protein plays a key role in amyotrophic lateral sclerosis via aggregation and toxicity.
1/2021	HDAC6 Interacts With Poly (GA) and Modulates its Accumulation in c9FTD/ALS.
12/2017	C9orf72 poly GA RAN-translated protein plays a key role in amyotrophic lateral sclerosis via aggregation and toxicity.
1/2017	Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss.
1/2016	C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins.
10/2015	Cerebellar c9RAN proteins associate with clinical and neuropathological characteristics of C9ORF72 repeat expansion carriers.

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Leonard Petrucelli Research Topics

Disease

44	Frontotemporal Dementia (Semantic Dementia) 01/2022 - 06/2006
43	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 11/2022 - 09/2007
34	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 01/2022 - 09/2007
30	Alzheimer Disease (Alzheimer's Disease) 12/2020 - 04/2005
28	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 04/2004
16	Tauopathies 10/2021 - 10/2006
14	Parkinson Disease (Parkinson's Disease) 01/2020 - 12/2002
10	Dementia (Dementias) 11/2020 - 07/2006
6	Atrophy 12/2020 - 01/2014
6	TDP-43 Proteinopathies 01/2020 - 07/2008
5	Machado-Joseph Disease (Spinocerebellar Ataxia Type 3) 01/2022 - 10/2020
5	Motor Neuron Disease (Primary Lateral Sclerosis) 01/2021 - 03/2014
4	Proteostasis Deficiencies 01/2022 - 07/2008
4	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 11/2020 - 06/2006
4	Cognitive Dysfunction 11/2018 - 07/2012
3	Gliosis 11/2020 - 10/2006
3	Amyloidosis 11/2020 - 01/2017
3	Hippocampal Sclerosis 01/2020 - 01/2017
3	Corticobasal Degeneration 01/2019 - 06/2006
3	Inflammation (Inflammations) 01/2017 - 07/2010
3	Parkinsonian Disorders (Parkinsonism) 06/2014 - 10/2007
3	Wounds and Injuries (Trauma) 01/2014 - 07/2010
2	Ataxia (Dyssynergia) 01/2021 - 10/2020
2	Disease Progression 01/2017 - 10/2016
2	Mitochondrial Diseases (Mitochondrial Disease) 10/2016 - 12/2013
2	Chronic Traumatic Encephalopathy 01/2014 - 01/2014
1	Cerebellar Ataxia (Dysmetria) 01/2022
1	Venous Thrombosis (Deep-Vein Thrombosis) 11/2021
1	Pulmonary Embolism 11/2021
1	COVID-19 01/2021
1	Stroke (Strokes) 11/2020
1	Brain Injuries (Brain Injury) 11/2020
1	Amyloid Plaque 01/2019
1	Neuroinflammatory Diseases 10/2018
1	Brain Diseases (Brain Disorder) 01/2018
1	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 01/2017
1	Prodromal Symptoms 01/2017
1	Xeroderma Pigmentosum (Kaposi's Disease) 01/2016
1	Pick Disease of the Brain (Pick's Disease) 01/2016

Drug/Important Bio-Agent (IBA)

42	Proteins (Proteins, Gene)FDA Link 01/2022 - 12/2002
26	DNA-Binding Proteins (DNA Binding Protein)IBA 11/2022 - 07/2008
15	ProgranulinsIBA 01/2021 - 09/2007
12	RNA (Ribonucleic Acid)IBA 01/2022 - 09/2013
11	DipeptidesIBA 01/2022 - 10/2013
10	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 09/2007
10	UbiquitinIBA 01/2014 - 04/2004
9	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2021 - 06/2006
9	tau Proteins (tau Protein)IBA 01/2019 - 06/2010
8	Amyloid (Amyloid Fibrils)IBA 01/2022 - 10/2006
8	RNA-Binding Proteins (RNA-Binding Protein)IBA 01/2022 - 08/2010
7	poly(glycyl-alanyl)IBA 01/2022 - 10/2015
7	Biomarkers (Surrogate Marker)IBA 01/2022 - 07/2017
6	polyglutamineIBA 01/2022 - 01/2009
5	Proteasome Endopeptidase Complex (Proteasome)IBA 07/2009 - 12/2002
4	Amyloid beta-PeptidesIBA 01/2019 - 04/2005
4	Pharmaceutical PreparationsIBA 10/2016 - 01/2007
3	Ataxin-3IBA 01/2022 - 10/2020
3	Protein Isoforms (Isoforms)IBA 01/2021 - 05/2010
3	Molecular Chaperones (Chaperone, Molecular)IBA 12/2020 - 04/2004
3	Biological ProductsIBA 10/2020 - 07/2012
3	NucleotidesIBA 01/2019 - 01/2018
3	Apolipoproteins E (ApoE)IBA 11/2018 - 01/2018
3	Phosphotransferases (Kinase)IBA 09/2010 - 10/2006
3	alpha-SynucleinIBA 06/2006 - 10/2003
2	SynucleinsIBA 01/2022 - 01/2020
2	Amino Acids FDA Link 01/2022 - 08/2015
2	Peptides (Polypeptides)IBA 11/2020 - 01/2017
2	Ribosomal Proteins (Ribosomal Protein)IBA 01/2019 - 10/2016
2	ApolipoproteinsIBA 10/2018 - 01/2014
2	Heat-Shock Proteins (Heat-Shock Protein)IBA 01/2018 - 01/2007
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 12/2012 - 07/2012
2	Carrier Proteins (Binding Protein)IBA 07/2012 - 07/2012
2	Leucine (L-Leucine)FDA Link 09/2010 - 02/2009
1	N-methyladenosineIBA 10/2021
1	Tumor Necrosis Factor Ligand Superfamily Member 14IBA 01/2021
1	remdesivirIBA 01/2021
1	Adenosine Monophosphate (AMP)IBA 01/2021
1	ClusterinIBA 12/2020
1	Nonsense Codon (Nonsense Mutation)IBA 01/2020
1	ChitinasesIBA 01/2020
1	GuanineIBA 01/2020
1	Green Fluorescent ProteinsIBA 01/2019
1	HLA-DQA2 antigenIBA 01/2019
1	PolymersIBA 01/2018
1	Transcription Factors (Transcription Factor)IBA 01/2018
1	RNA Polymerase II (RNA Polymerase B)IBA 01/2017
1	Peptide Hydrolases (Proteases)FDA Link 01/2017
1	ElementsIBA 01/2017
1	AntioxidantsIBA 01/2017
1	Heterogeneous-Nuclear Ribonucleoprotein KIBA 01/2017
1	Apolipoprotein E4IBA 01/2017
1	Presenilin-1IBA 01/2017
1	PrionsIBA 04/2016
1	Heterogeneous Nuclear Ribonucleoprotein A1IBA 02/2016
1	Ubiquitinated ProteinsIBA 01/2016
1	7- (6- fluoropyridin- 3- yl)- 5H- pyrido(4,3- b)indoleIBA 01/2016
1	Lysine (L-Lysine)FDA Link 08/2015
1	AsparagineIBA 08/2015

Therapy/Procedure

11	Therapeutics 01/2022 - 01/2012
1	Length of Stay 11/2021